Many people can achieve long-term remission by correcting the biological imbalances that drive inflammation. IBD isn’t random, and flare-ups don’t happen “out of nowhere.” When we identify and fix the root causes, the body stabilizes.

Crohn’s and Ulcerative Colitis can enter deep, lasting remission when the underlying drivers are addressed. Most clients improve once we correct:

• Immune pathway imbalance (TH1/TH2/TH17 dominance, low Tregs)

• Bile acid dysfunction (bile acid malabsorption, impaired flow)

• Microbiome collapse (loss of keystone species, fungal overgrowth, SIBO)

• Mold and mycotoxin toxicity (TLR4 activation, mitochondrial suppression)

• Chronic histamine overload (mast-cell activation, impaired DAO function)

• Nutrient deficiencies (zinc, magnesium, B vitamins, minerals)

• Stress physiology & vagus nerve shutdown

IBD symptoms make sense when we address these mechanisms—and remission becomes achievable.

👉 Check out: Treatments and Conditions We Help

Biologics only target one immune pathway, but most IBD cases involve multiple pathways. Over time, untreated pathways continue driving inflammation.

Biologics often stop working because Crohn’s and Colitis rarely involve a single immune mechanism. IBD typically includes:

• TH1 dominance (deep tissue inflammation)

• TH2 histamine activation

• TH17 overexpression (auto-inflammatory cycles)

• Regulatory T-cell suppression (loss of immune braking system)

A biologic may block TNF-α, IL-23, or IL-12, but if TH17, histamine pathways, or Treg suppression remain unaddressed, inflammation shifts to another lane.

This is why treating the entire immune pattern, not one cytokine, produces better long-term outcomes.

👉 Check out: Immune Pathways Blog/Page, Start Here Page

Yes. Mold exposure and mycotoxins can trigger or worsen Crohn’s and Colitis by disrupting immune balance, damaging mitochondria, weakening the gut lining, and increasing inflammation.

Mold is one of the most overlooked root causes of IBD flares. Mycotoxins can:

• Activate TLR4 (a major inflammatory pathway tied to gut permeability)

• Suppress Treg cells (raising auto-inflammatory activity)

• Increase histamine and mast-cell activation

• Damage mitochondria (slowing healing and repair)

• Disrupt bile acids (triggering diarrhea and fat malabsorption)

• Drive fungal overgrowth (Candida, Aspergillus-related symptoms)

For many clients, addressing mold toxicity is what finally stabilizes the gut.

Check out: Mold & IBD Page, and Testing & Labs Page

There is no universal IBD diet. The best diet depends on immune dominance, bile acid status, histamine patterns, and microbial balance.

Choosing the right diet requires understanding your biology. Diet should be based on:

Your Immune Pattern

• TH1-dominant → lower lectins, avoid immune triggers

• TH2/histamine-dominant → lower histamine diet

• TH17 dominant → anti-inflammatory + polyphenol support

Your Bile Acid Status

• Bile acid malabsorption → lower fat, bile acid binders, bile support

• Low bile flow → bitters, TUDCA, phosphatidylcholine

Microbiome Patterns

• Fungal overgrowth → lower sugar

• SIBO → lower fermentable carbs

• Dysbiosis → phase-specific prebiotics

General principles for IBD stability:

• Simple whole foods

• Low-inflammatory proteins

• Easily digestible fruits/vegetables

• Avoiding emulsifiers, seed oils, gums

• Matching foods to digestive capacity

Diet works when it matches your physiology—not when it follows generic rules.

👉 Check out: Start Here Page, Natural Treatments Page

The best supplements support bile flow, immune balance, mitochondria, and microbial repair—NOT just symptom relief.

Different people need different formulas, but the most clinically relevant categories for IBD include:

Immune Modulation

• Treg support

• Mast-cell stabilizers (quercetin, luteolin, perilla extract)

• TH1/TH17 balancing nutrients (vitamin D, zinc, omega-3s)

Bile & Digestion

• Bile acids (ox bile, TUDCA)

• Digestive enzymes

• Phosphatidylcholine

Microbiome Rebuilding

• Spore probiotics (DE111, HU36/HU58)

• Phage-based prebiotics (PreforPro)

• Butyrate

Mitochondria & Repair

• NAC

• CoQ10

• Electrolytes & trace minerals

• Glutamine (only when fungal markers are low)

Mold detox (when relevant)

• Binders (charcoal, clay, zeolite, chitosan)

• Liver support

Supplements work best inside a structured, root-cause protocol—not randomly.

👉 Check out: Supplements Page, Testing & Labs Page

The right tests reveal the root causes of inflammation—not just the damage from it.

To understand Crohn’s or Colitis at the root, functional testing is essential. The most informative tests include:

GI & Microbiome

• GI-MAP (bacteria, fungi, viruses, parasites, sIgA, calprotectin)

• Calprotectin (inflammation severity)

• Secretory IgA (immune depletion or activation)

Metabolic & Mitochondria

• Organic Acids Test (OAT)

  • fungal markers

  • mitochondrial status

  • detox pathways

  • oxalates

Mold & Toxins

• Mycotoxin Panel

• HTMA (Hair Tissue Mineral Analysis) for detox + mineral patterns

Bile & Digestion

• Bile acid testing

• Liver enzymes

• Markers of fat malabsorption

Immune Patterns

• Vitamin D

• CRP

• ESR

• CBC with differential

Each test reveals missing pieces of the IBD puzzle—and together they map your treatment path.

👉 Check out: Testing & Labs Page, Natural Treatments Page, Start Here Page